Aspermatogenesis, Anaphylaxis, and Cutaneous Sensitization Induced in T H E Guinea Pig by Homologous Testicular Extract* by Jules

I t has been shown that a single intracutaneous injection of autologous or homologous spermia, or testicular suspension incorporated in a water-in-oil emulsion containing killed mycobacteria, induces aspermatogenesis in the guinea pig (1). This process results in the degeneration, necrobiosis, and elimination of most of the germinal cells without injury to the Leydig cells or accessory genital organs, such as the seminal vesicles and the prostate. The purpose of the present paper is to give an account of an effort to purify the antigenic material, and of observations on anaphylactic systemic and cutaneous sensitizations to homologous testicular extracts.